Movie EV8
Video of an embryo expressing GFP-MCM-10 and mCherry-Histone H2B, treated with cdc-45 RNAi and progressing throughout the first embryonic S phase. 
Embryo shown in Figure 2A, cdc-45 RNAi (GFP-MCM-10 in the left panel, mCherry-H2B on the right).  Frames 25, 28, 31, 35 and 40 correspond to the 0’, 0.5’, 1’, 1.5’ and 2.5’ timepoints in Figure 2A.  The images in the movie are rotated by 90° with respect to the data in Figure 2A.